Diplomatic breakthrough on Iran's nuclear program and relations with the West is unlikely at the UN General Assembly (UNGA) due to complex dynamics and underlying obstacles. Iran's new president, Masoud Pezeshkian, has signaled a more conciliatory approach and openness to negotiations, but Iran's continued nuclear advancements and escalating tensions with Israel hinder progress. The dire economic situation in Iran, worsened by years of sanctions, motivates the country's willingness to negotiate. However, the mistrust between Iran and the West, Iran's support for Russia in the Ukraine conflict, and the strategic alliance between the US and Israel pose significant challenges to any comprehensive diplomatic initiative.