Iran's supreme leader, Ayatollah Ali Khamenei, has warned that if the US threatens Iran's security, Iran will respond in kind. Khamenei's comments come after US President Donald Trump expressed interest in nuclear talks with Tehran. The supreme leader stated that negotiations with the US are not intelligent, wise, or honorable. Khamenei's remarks contradict previous signals from Tehran that it wants to negotiate over its nuclear program in exchange for the lifting of economic sanctions. The next steps in the US-Iran relationship remain uncertain.