Researchers at Osaka University in Japan have successfully restored vision in patients with limbal stem-cell deficiency (LSCD) using induced pluripotent stem cells (iPS) to perform corneal transplants. The study involved four participants who all experienced an immediate improvement in eyesight following the transplants. Three participants with severe vision impairment saw significant and lasting improvements in their vision for over a year. The researchers are now focusing on testing the safety and durability of new stem cell applications and will begin clinical trials in March 2025 to further evaluate the efficacy of the treatment.