Syria's regime is on the verge of losing its northern city of Aleppo to Syrian opposition groups led by Hayat Tahrir al-Sham (HTS) due to its weakness and the weakening of Iran's backing. This could deal the Bashar al-Assad regime its largest blow in years. The regime believed its backers in Moscow and Tehran could keep it safe, but it is now fleeing as HTS conquers dozens of villages and marches into Aleppo. The weakened Syrian regime is now vulnerable as Russia focuses on Ukraine and Israel has smashed Hezbollah. This shows the unintended consequences of Iran's policy and weakens Iran's position in the region.