Israeli founders are preparing to capitalize on the opportunities that the new year brings, but the path to start-up success is filled with obstacles. A proactive mindset is essential to drive progress and overcome obstacles. The five key factors for start-up success in 2025 include targeting the right market, raising the appropriate amount of capital, building the right team, understanding the competition, and solving a real problem. By addressing these factors, founders can position their start-ups to navigate challenges and capitalize on opportunities effectively.