A new study published in the journal Nature Metabolism found that specific neurons in the hippocampus store food-related memories, directly influencing overeating and body weight. These neurons play a role in excessive food intake and diet-induced obesity. Silencing these neurons reduces sugar consumption and prevents weight gain in mice, while reactivating them enhances food-related memories and increases food consumption. By targeting hippocampal memory circuits, it may be possible to disrupt memories that stimulate the consumption of calorie-rich foods, offering a method to combat overeating and obesity.